Transplanting Hepatitis C Kidneys Into Negative KidnEy Recipients

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Why should we use kidneys from HCV infected donors?

  • Patients usually wait at least 3-5 years for a kidney transplant
  • Dialysis decreases quality of life and patients on dialysis can experience worsening of their health
  • Some patients die while waiting for a kidney transplant
  • Hepatitis C can be cured with new medications
  • Most kidneys from donors with hepatitis C work well

What are the benefits of the study?

  • Have less time on dialysis before transplant
  • Receive a kidney transplant faster
  • Receive a kidney from a younger donor
  • Can still receive a kidney from a donor who does not have hepatitis C if hepatitis C-negative kidney is available sooner

What are the risks of the study?

  • Severe liver damage from hepatitis C may happen after the kidney transplant
  • The medication to treat hepatitis C may not work as well in transplant patients


What are the study procedures?

  • You will need blood and other tests to make sure you can be in the study
  • The transplant waiting list will show that you are willing to accept a kidney from a donor with hepatitis C
  • The donor kidney is biopsied prior to or around the time of the transplant
  • After transplant, you will be treated with Epclusa (Sofosbuvir + Velpatasvir) for 3 months. The drug is free to you.
  • If you are not cured of hepatitis C after 3 months, you will be treated with Vosevi (Sofosbuvir + Velpatasvir + Voxilaprevir)
  • Your study visits will be scheduled on the same day as your normal transplant visits whenever possible